RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
miR-122-5p
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
the dual-luciferase assay
Target
HIF-1 alpha
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
Apigenin suppresses TGF-beta1-induced cardiac fibroblast differentiation and collagen synthesis through the downregulation of HIF-1 alpha expression by miR-122-5p.
Year
2021
Function
"Apigenin could suppress the differentiation and collagen synthesis of TGF-beta1-stimulated cardiac fibroblasts and mouse cardiac fibrosis, and its mechanisms were related to the increment of miR-122-5p expression and subsequent downregulation of HIF-1 alpha expression via direct interaction, which might finally result in the decrements of Smad2/3 and p-Smad2/3 expressions and increment of Smad7 expression."